Every now and then we get asked about Slash’s amp settings or how to get the “Slash sound”. You should keep in mind that much of the “tone” comes from the way you play the guitar. Your hands, your technique and your style make up a big part of YOUR (or Slash’s) sound.
However, if you want to get closer to Slash’s amp sound, it’s a good idea to start with a Marshall. Preferably a JCM Slash, a Silver Jubilee or a JCM 800. But you can get pretty close with any other Marshall as well. The handbook that you get with the Slash Signature amp includes settings that build a good foundation for the Slash sound.
But Slash uses an array of additional equipment that you can see here.
To print a copy of the handbook, go here:

Download the handbook (pdf)
UPDATE:
As Slashwannabe1 pointed out in the forum, he’s got an image of Slash’s settings that are different:

And Adam Day gave him these settings for the Vintage Modern that Slash also used briefly:
High dynamic range
Mid Boost out
Body = 2
Detail = 5.5
Treble = 5
Middle = 7
Bass = 6.5
Presence = 4.5
Master Vol = 9
Reverb = off
And if you’ve got one of the AFD100 amps, here’s a photo of the settings posted by Stoof on the mylespaul forum:





